Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy
Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression.Here, we propose a self-amplifying logic-gated gene editing s