LOGIC-GATED TUMOR-MICROENVIRONMENT NANOAMPLIFIER ENABLES TARGETED DELIVERY OF CRISPR/CAS9 FOR MULTIMODAL CANCER THERAPY

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression.Here, we propose a self-amplifying logic-gated gene editing s

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The effect of pumpkin seed cake and ground cloves (Syzygium aromaticum) supplementation on gastrointestinal nematode egg shedding in sheep

The aim of this study was to evaluate the effect of feed additives (pumpkin seed cake and cloves) on the egg excretion of gastrointestinal nematodes (GIN) in sheep.Thirty ewes STATIONARY naturally infected with GIN were randomly selected from a flock and assigned to the following groups of 10 animals each: clove group (received 1.8 g ground cloves/

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Resilience of Sphyrna lewini, Rhizoprionodon longurio, and Carcharhinus falciformis at the entrance to the Gulf of California after three decades of exploitation

Given their biological characteristics, sharks exhibit low resilience and thereby are considered a fishery resource particularly vulnerable to overfishing.Yet, for several decades, three shark species (Sphyrna lewini, Rhizoprionodon longurio, and Carcharhinus falciformis) have contributed consistently to the catches of the artisanal shark fishery a

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